_:vb50937669 . _:vb50937669 "A heart valve disease that is characterized by repeated inflammation with fibrinous repair caused by an autoimmune reaction to Group A beta-hemolytic streptococci (GAS) that results in valvular damage. The cardinal anatomic changes of the valve include leaflet thickening, commissural fusion, and shortening and thickening of the tendinous cords."^^ . _:vb50937669 . _:vb50937669 . _:vb50937669 "url:http://en.wikipedia.org/wiki/Rheumatic_heart_disease"^^ . _:vb50937669 . _:vb50937669 .