. . . "Predicting the antimicrobial efficacy of hydrogen bonded, self\u2010associating amphiphiles"^^ . . . . . . . . . "2020-09-15" . . . . . . . . . . . "Herein, we report 50 structurally related supramolecular self\u2010associating amphiphilic (SSA) salts and related compounds. These SSAs are shown to act as antimicrobial agents, active against model Gram\u2010positive (Methicillin\u2010Resistant Staphylococcus aureus ) and/or Gram\u2010negative ( Escherichia coli ) bacteria of clinical interest. Through a combination of solution state, gas phase, solid state and in silico measurements we determine 14 different physicochemical parameters for each of these 50 structurally related compounds. These parameter sets are then used to identify molecular structure \u2013 physicochemical property \u2013 antimicrobial activity relationships for our model Gram\u2010negative and Gram\u2010positive bacteria, while simultaneously providing insight towards the elucidation of SSA mode of antimicrobial action."^^ . . . . . . . . . . . . . . . . . . . . . . . .