"A tyrosinemia that has_material_basis_in deficiency of the enzyme fumarylacetoacetate hydrolase resulting in an increase in fumarylacetoacetate which inhibits previous steps in tyrosine degradation leading to an accumulation of tyrosine in the body."^^ . _:vb50937475 . _:vb50937475 . . "DOID:0050726"^^ . "2012-07-06T02:55:45Z"^^ . . "tyrosinemia type I"^^ . "OMIM:276700"^^ . _:vb50937475 . "hepatorenal tyrosinemia"@en . . _:vb50937475 . "lschriml"^^ . _:vb50937475 . "disease_ontology"^^ .