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Subject Item
n2:93613
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n3:EPrint bibo:Article n3:ArticleEPrint bibo:AcademicArticle
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n16:j.sjbs.2022.03.014
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dcterms:title
Novel Molecular classification of colorectal cancer and correlation with survival
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2022-03-10
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n10:ext-abd6b02abbfc68a7bd4f735b4f67f964 n10:ext-864b8bc53cf74cbe8b8aac0131a023ae n10:ext-767afad625753759be39deeec78d04eb n10:ext-d.soria@kent.ac.uk n10:ext-8d3607da8f108700210de40953a25d6a n10:ext-250268e63463ba338843cd27c8973050 n10:ext-05e0e7bf235bba43cec1c1e0f05410f2
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bibo:abstract
Colorectal cancer (CRC) is one of the most common cancers worldwide. This study was designed to evaluate biological patterns, explore molecular classification and correlate with survival outcome in treatment naïve CRC patients. Methods Over 11 years consecutive series of 435 CRC patients were operated on as primary surgical therapy. A total of 201 CRC patients were included, whose complete set of clinical information was available, and their good quality tumour blocks were retrieved. Immunohistochemistry was used for tumour analysis, and partitional clustering was performed using R software for cluster analysis. Results The median age was 43 (range 10-85) years; adenocarcinoma was the most commonly seen histological type. The great majority had positive CK20, CEA, E-Cadherin, Ki67, CDX2, and p53 expression. There were four distinct molecular classes found, whereas Ki67, CDX2, and p53 play 3 the main role in partitioning. Younger age negatively impacted survival; overall and diseasespecific survival was 26 months only with 50 months’ longest survival. Conclusion Colorectal cancer is a biologically heterogeneous disease with at least four distinct molecular patterns, where cell proliferation and gene repair mechanisms appear to play the key role.
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