leukoencephalopathy with swelling and cystsVan Der Knaap disease
obo:hasOBONamespace
disease_ontology
n2:IAO_0000115
A megalencephalic leukoencephalopathy with subcortical cysts characterized by early-onset macrocephaly and delayed-onset neurologic deterioration, including cerebellar ataxia, spasticity, epilepsy, and mild cognitive decline, that has_material_basis_in homozygous or compound heterozygous mutation in MLC1 on chromosome 22q13.